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Buy colchicine 500 microgram tablets of Colchicine to 6 dogs, and for the second dog, treated with colchicine 500 microgram tablets of Colchicine, at intervals up to 8 weeks; – for the treatment of an allergic rhinitis associated with bacterial or fungal rhinorrhea in 2 dogs with nasal congestion of the nose and sinusitis (1 dog), treated with 5 mL/kg of metronidazole cream (2 times daily for 3 days) followed by 2 mL/kg of colchicine (2 times daily for 2 days) administered hours before the first treatment with metronidazole cream, and – for the treatment of an allergic rhinitis associated with bacterial or fungal rhinorrhea secondary to a viral infection (2 dogs), treated with 5 mL/kg of metronidazole cream (2 times daily for 3 days) followed by 1 mL/kg of colchicine (2 times daily for 1 day) during the period 8 weeks prior to the subsequent treatment with metronidazole cream. – In combination with metronidazole cream, colchicine was as highly efficacious metronidazole alone according to the mean (± standard deviation) of all efficacy assessments. The clinical efficacy and safety data were comparable in the 2 treatment groups of dogs after 8 weeks therapy. The incidence of adverse effects observed during the acute treatment phase was similar between the 2 treatment groups of dogs; however, for the colchicine-treated dogs, incidence of treatment-emergent adverse events (TEAE) was greater than those observed in the metronidazole-treated dogs (Table 5). Among all the TEAEs observed, main adverse events observed were sneezing, sneezing rhinorrhoea, chest, stools and a decrease in lung function (Table 2). All the dogs in both treatment groups recovered from all TEAEs within 24-48 h after the first dose of treatment. Discussion Cochicine (Astragalus membranacea L.) is the active component of plant and has been reported to be effective against many clinical diseases. The present study demonstrated that in the buy cheap colchicine treatment of an allergic rhinitis as discussed above there were marked improvements (30-50%) in efficacy and safety dogs treated with a combination of daily dose metronidazole cream and colchicine at doses effective in treating nasal congestion and a primary rhinitis in dogs, according to the mean (± standard deviation) efficacy assessment of all the dogs following 8-week treatment. The increase in efficacy and safety associated with this study indicates that a synergistic or combined combination of metronidazole and colchicine at therapeutic doses is effective in the treatment of nasal congestion associated with an allergic rhinitis according to the median results obtained (3.6% for both treatments), while an efficacious combination of metronidazole and corticosteroids at doses effective in treating a primary rhinitis according to the median results obtained may be used in dogs with a primary rhinitis (2.2% for both treatments). It is recommended that the application of one these 2 agents may serve different patients depending on the disease severity and degree of symptoms. In addition, we observed that an additional treatment dose of metronidazole was sufficient in treating nasal congestion caused by an.

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